Genetech

Female Infertility - Poor Oocyte Retrieval

How GFA helped a couple with multiple failed cycles, with poor oocyte retrieval and poor embryo quality in IVF.

Couple was struggling with multiple IVF failures – 4 IUI, 1 IVF and 2 ICSI. Ovarian induction yielded fewer oocytes with average to poor quality leading to implantation failures. GeneFeminaTM analysis not just identified the root cause of poor response to ovarian stimulation in female partner, but also suggested the best suited protocol for success.

Preethi’s medical reports showed AMH on lower side. Sriram’s semen analysis was normal with good count, motility and morphology. Partners were keen to conceive with their self gametes and were not ready for donor gametes. At the point when the couple was about to give up all fertility treatments, a Hyderabad based fertility expert referred Preethi for GeneFeminaTM test to find out if there are any other options to pursue. Genomic Fertility Analysis (GFA) of Preethi by GeneFeminaTM showed presence of a LHB genotype revealing the cause of poor response to controlled ovarian stimulation in previous cycles. Along with LHB genotype a few other risk genotypes associated with implantation failure related to inflammation pathways were also discovered. Research indicates that women with LHB genotype respond well to a specific protocol of ovarian induction using exogenous LH. The GeneFeminaTM report recommended LH stimulation. Physician took a note of this pharmacogenomic implication and planned controlled ovarian stimulation with LH stimulation rather than the standard FSH protocol. The recommended protocol of ovarian induction yielded better oocyte retrieval and with better quality. Eight embryos were fertilized and two were transferred. Anti-inflammatory and anti-coagulant therapy was given to prevent placental cell inflammation related implantation failures. A positive pregnancy test was achieved and the couple delivered twins.

Female Infertility - Poor Oocyte Retrieval

How GFA helped a couple with multiple failed cycles, with poor oocyte retrieval and poor embryo quality in IVF.

Couple was struggling with multiple IVF failures – 4 IUI, 1 IVF and 2 ICSI. Ovarian induction yielded fewer oocytes with average to poor quality leading to implantation failures. GeneFeminaTM analysis not just identified the root cause of poor response to ovarian stimulation in female partner, but also suggested the best suited protocol for success.

Preethi’s medical reports showed AMH on lower side. Sriram’s semen analysis was normal with good count, motility and morphology. Partners were keen to conceive with their self gametes and were not ready for donor gametes. At the point when the couple was about to give up all fertility treatments, a Hyderabad based fertility expert referred Preethi for GeneFeminaTM test to find out if there are any other options to pursue. Genomic Fertility Analysis (GFA) of Preethi by GeneFeminaTM showed presence of a LHB genotype revealing the cause of poor response to controlled ovarian stimulation in previous cycles. Along with LHB genotype a few other risk genotypes associated with implantation failure related to inflammation pathways were also discovered. Research indicates that women with LHB genotype respond well to a specific protocol of ovarian induction using exogenous LH. The GeneFeminaTM report recommended LH stimulation. Physician took a note of this pharmacogenomic implication and planned controlled ovarian stimulation with LH stimulation rather than the standard FSH protocol. The recommended protocol of ovarian induction yielded better oocyte retrieval and with better quality. Eight embryos were fertilized and two were transferred. Anti-inflammatory and anti-coagulant therapy was given to prevent placental cell inflammation related implantation failures. A positive pregnancy test was achieved and the couple delivered twins.

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Female Infertility - Poor Oocyte Retrieval

Couple was struggling with multiple IVF failures – 4 IUI, 1 IVF and 2 ICSI. Ovarian induction yielded fewer oocytes with average to poor quality leading to implantation failures. GeneFeminaTM analysis not just identified the root cause of poor response to ovarian stimulation in female partner, but also suggested the best suited protocol for success.

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