Early diagnosis of premature ovarian insufficiency by GeneFeminaTM helped in achieving fertility, by taking early decisions on treatment. Cryopreserving embryos helped in avoiding multiple, not so pleasant, induction cycles.
Jugnu, a 27yr old busy professional, approached her family gynecologist in Mumbai with complaint of irregular periods and not being able to conceive. Her medical investigations showed that she has high FSH (Follicle stimulating hormone) and low AMH (Anti Mullerian Hormone) which are important hormones for female fertility function. On doctor’s advice she made several changes to her lifestyle and also reduced weight with regular exercise without success. The Gynecologist ordered GeneFeminaTM to understand the reason for infertility. Genomic Fertility Analysis by GeneFeminaTM revealed that Jugnu carried a genotype in NOBOX gene which results in premature ovarian Insufficient (POI), a condition where the ovary gets depleted of oocytes rapidly and progresses towards early menopause. Since the ovary does not produce enough oocytes that are matured, the condition causes irregular periods, secondary amenorrhea (cessation of menstruation) and infertility along with several other side effects that are seen in women at the age of menopause. It is advisable that women with POI undergo fertility treatment as early as possible in view of ovarian depletion. Also, the genotype in Jugnu indicates that her ovaries may respond poorly to stimulation and therefore would need higher doses during controlled ovarian stimulation. In addition, embryo cryopreservation was strongly recommended to avoid multiple stimulations in case of IVF cycle failure. Jugnu approached an infertility clinic in Mumbai with GeneFeminaTM results and underwent ovarian induction with higher doses, got 15 oocytes retrieved, 8 fertilized embryos of good quality, transferred one and cryopreserved the rest. She conceived in her second cycle with frozen embryo transfer and delivered a healthy child.
