Chief Guest 9M CME  

Original article Improved ART success with GeneFemina in Fertility Science and Research 2023

The paper was jointly written and published by Dr. Aradhya Achuri, a leading IVF specialist in Hyderabad and Dr. Anuradha Udumudi, Founder Director, GeneTech. The article demonstrates identification of hypo-responders and customization of controlled ovarian stimulation protocols based on genomic analysis combined with clinical parameters leading to reduction in number of cycles and improving outcome or reproductive success. The paper showcases pharmacogenomics and personalised medicine as a promising approach in the field of ART.

A study published in the American Journal of Human Genetics investigated the prevalence and impact of nonsense single nucleotide polymorphisms (SNPs) in the human genome. These variants introduce premature stop codons, potentially leading to truncated, nonfunctional proteins. By genotyping 805 nonsense SNPs across 1,151 individuals from 56 populations, researchers identified 169 genes with variable nonsense SNPs, with 99 genes showing inactivation in at least one individual. On average, individuals differed by 24 genes due to these SNPs alone. While most nonsense SNPs are slightly disadvantageous over evolutionary timescales, some may be advantageous, indicated by high population differentiation and frequency.