Chapter on basics and clinical applications of PGT in ART in the book Fertility Update (2024).

The clinical utility of testing embryos is clearly demonstrated in last two decades and PGT is increasingly used in fertility centres to not only avoid genetic conditions in the offspring but to also improve IVF outcomes. PGT is used to detect numerical chromosomal defects, structural defects and single gene or monogenic genetic disorders in the embryos. Indications for PGT recommendation mostly include women with advanced maternal age, recurrent pregnancy losses, recurrent IVF failures and family history of genetic disorders. The chapter covers types of PGT, benefits, limitations, internation guidelines and follow up requirements in post-PGT pregnancies.