Pharmacogenomics – Male infertility
Case Report on Favourable outcome with r-FSH treatment and FSHR gene variant in Fertility Science and Research (2021).
Authored by Dr. Anuradha Udumudi and Dr. Narmada Katakam, the study demonstrates that r-FSH administration in a man with idiopathic infertility and severe OATS carrying homozygous N680N FSHR genotype resulted in improved sperm quality and reduced sperm DFI, eventually leading to conception in first cycle of ICSI. It was proposed that FSHR Ser680Asn genotype may serve as a clinically useful pharmacogenomic marker to identify good responders to r-FSH treatment. The paper discusses the duration and dosage of the treatment.
Pharmacogenomics – Male infertility
Chief Guest 9M CME
Case Report on Favourable outcome with r-FSH treatment and FSHR gene variant in Fertility Science and Research (2021).
Authored by Dr. Anuradha Udumudi and Dr. Narmada Katakam, the study demonstrates that r-FSH administration in a man with idiopathic infertility and severe OATS carrying homozygous N680N FSHR genotype resulted in improved sperm quality and reduced sperm DFI, eventually leading to conception in first cycle of ICSI. It was proposed that FSHR Ser680Asn genotype may serve as a clinically useful pharmacogenomic marker to identify good responders to r-FSH treatment. The paper discusses the duration and dosage of the treatment.
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